R and Bioconductor solutions for alternative splicing detection
نویسندگان
چکیده
منابع مشابه
Role of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملDetection and measurement of alternative splicing using splicing-sensitive microarrays.
Splicing and alternative splicing are major processes in the interpretation and expression of genetic information for metazoan organisms. The study of splicing is moving from focused attention on the regulatory mechanisms of a selected set of paradigmatic alternative splicing events to questions of global integration of splicing regulation with genome and cell function. For this reason, paralle...
متن کاملModel-based detection of alternative splicing signals
MOTIVATION Transcripts from approximately 95% of human multi-exon genes are subject to alternative splicing (AS). The growing interest in AS is propelled by its prominent contribution to transcriptome and proteome complexity and the role of aberrant AS in numerous diseases. Recent technological advances enable thousands of exons to be simultaneously profiled across diverse cell types and cellul...
متن کاملScalable Genomics with R and Bioconductor
This paper reviews strategies for solving problems encountered when analyzing large genomic data sets and describes the implementation of those strategies in R by packages from the Bioconductor project. We treat the scalable processing, summarization and visualization of big genomic data. The general ideas are well established and include restrictive queries, compression, iteration and parallel...
متن کاملAlternative Splicing Detection Algorithms for Affymetrix Exon Array Data
Generating a variety of transcripts from a single gene is common in many organisms. This process, called alternative splicing, can be found in all classes of eukaryotes. In lower eukaryotes only a small fraction of genes undergoes alternative splicing, while in higher eukaryotes nearly all genes are alternatively spliced[1]. The function of this process is to increase the protein diversity [2]....
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ژورنال
عنوان ژورنال: Human Genomics
سال: 2009
ISSN: 1479-7364
DOI: 10.1186/1479-7364-4-2-131